Police Col. Paulo Henrique Hemm told the G1 news portal that at least a dozen other people were injured and taken to nearby hospitals.
Hemm said the cause was still under investigation but that it appeared the driver might have lost control on a curve and the bus then ran off the road and fell into a ravine that is 400 meters (1,300 feet) deep.
He said the accident happened in a mountainous area of Santa Catarina state.
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