South Africa won by an innings and 74 runs when England were bowled out for 169 in their second innings in the last over before lunch.[break]
Only Paul Collingwood stood firm for England, scoring 71 on a morning during which seven wickets fell for 121 runs.
Morkel finished with four for 59. He and Dale Steyn shared 14 wickets in a match dominated by the fast bowlers.
Collingwood batted aggressively at the start of the day, scoring most of the runs and taking most of the strike as he and Kevin Pietersen added 36 runs in 40 minutes to the overnight total of 48 for three.
South African newcomer, left-arm fast bowler Wayne Parnell, made the breakthrough when Pietersen chased a wide delivery, slanting away from him, to be caught behind by Mark Boucher for 12.
It completed a disappointing series for Pietersen, who scored 177 runs in four matches at an average of 25.28.
Ian Bell made only five before he was Morkel´s first victim of the day, fending a sharply-lifting delivery to Jacques Kallis at second slip.
Two balls later Matt Prior was out without scoring when an attempted hook looped off a top edge and Graeme Smith was able to run back from first slip to take the catch.
In Morkel´s next over Stuart Broad gloved a catch down the leg side to Boucher. He was given not out by umpire Steve Davis but South Africa successfully sought a review.
Graeme Swann batted with his customary aggression, making 20 off 17 balls, before he edged an out-swinger from Dale Steyn to AB de Villiers at third slip.
Collingwood´s fighting innings ended when JP Duminy was brought on to bowl his off-spinners. His first ball was a long hop which Collingwood pulled straight to Morkel at deep backward square leg.
Collingwood made 71 off 88 balls with 12 fours and a six.
Duminy wrapped up the win when Ryan Sidebottom swung and missed to bowled by the fifth ball of the final over before lunch.
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