England leads the five-match series 1-0, keeping the home team under pressure after the tourists also won the recent test series.
England kept the same team that won the first ODI in Bloemfontein in a rain-shortened match. That meant left-arm seamers David Willey and Reece Topley were given another chance to lead England's fast bowling attack.
Having conceded 399 to England's batsmen in the series opener, South Africa made two changes among its fast bowlers, recalling Kagiso Rabada and Kyle Abbott to replace Marchant de Lange and Chris Morris. Rabada was rested for the first one-day game, while Abbott returns after a hamstring injury.
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Lineups:
South Africa: AB de Villiers (captain), Quinton de Kock, Hashim Amla, Faf du Plessis, JP Duminy, Rilee Rossouw, Farhaan Behardien, Kagiso Rabada, Kyle Abbott, Morne Morkel, Imran Tahir.
England: Eoin Morgan (captain), Jason Roy, Alex Hales, Joe Root, Jos Buttler, Ben Stokes, Moeen Ali, Chris Jordan, Adil Rashid, David Willey, Reece Topley.
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