Police late Thursday night arrested the woman they say stabbed the man in the neck on Wednesday.
Police Officer Robert Heims tells the San Diego Union-Tribune that the 39-year-old man had walked up to a woman and a group of others and asked them for a cigarette in the city's East Village.
They say the woman then told the man to get away from her things before stabbing him and running away. They say the heavyset woman with facial hair was wearing a white shirt and jeans.
The man was hospitalized, but he is expected to survive.
Three arrested on charge of stabbing a youth to death in Tokha